Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

<table>Hydrogen bonding network between Gln9 and Ser6 from a given molecule of the mTS-dUMP-Raltitrexed complex structure (blue) and Glu32 and Asp11 from a neighboring molecule in the crystal lattice (green).</table>

BioMed Research International

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Figure 2: Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations 

Figure 2 | Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations 