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BioMed Research International
Volume 2014, Article ID 945803, 7 pages
Research Article

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

1Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland
2Institute of Bioorganic Chemistry, Polish Academy of Sciences, 12/14 Noskowskiego Street, 61-704 Poznań, Poland

Received 21 February 2014; Revised 13 May 2014; Accepted 16 May 2014; Published 3 June 2014

Academic Editor: David Stammers

Copyright © 2014 Anna Dowierciał et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Legend to Supplementary Figure 1S: Two antiparallel arrays of N-terminal non-polar residues stabilizing the molecular crystal packing of the mTS-dUMP-Raltitrexed complex structure.

  1. Supplementary Figure