Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia

Table 3

The parameters assessing the ability of ammonia concentration to recognize undetectable (<30 IU/L) ASP activity (95% CI in brackets).

	The ammonia concentration after ASP administration
	24 hours ≤ 38 𝜇mol/L	3 days ≤ 24 𝜇mol/L
Sensitivity	0.80 (0.50–0.94)	0.75 (0.47–0.91)
Specificity	0.90 (0.89-0.90)	0.74 (0.73–0.75)
Positive predictive value	0.21 (0.13–0.25)	0.09 (0.06–0.12)
Negative predictive value	0.99 (0.98–1.0)	0.99 (0.97–1.0)