Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

Table 5

Summary of themode of administration and delivery form ofVEGF, its advantages, and disadvantages (adapted from Keifer et al., 2014 [198]).

Administration
Direct	Indirect/Remote
(i) Direct access to the target area; (ii) Decreases complications in areas outside the therapeutic scope; (iii) Smaller dose required	(i) The product is delivered in the CNS secondarily; (ii) Necessary higher dosages; (iii) Less invasive administration; (iv) Product should have the ability to cross the BBB, pial barrier, and be transported retrogradely by CNS
Delivery
Cells that produce or secrete VEGF-A; Use of a viral vector or nonviral to produce VEGF-A or a protein that enhances expression of endogenous VEGF-A (transcription factor); Immediate delivery of VEGF-A protein to the target region