Beta-Catenin and Epithelial Tumors: A Study Based on 374 Oropharyngeal Cancers
Cytoplasmic delocalization with high expression of beta-catenin (a)–(d) and cytoplasmic delocalization of beta-catenin with immunostaining absence of marker (e)-(f). Cytoplasmic delocalization with high expression of beta-catenin has been prevalently observed in OSCCs/OPSCCS of the tongue, trigonous, gingival mucosa, jaw, and in the tumors sited on the floor of the mouth, on the alveolar ridge, and, finally, in the multifocal neoplasias () (a). This immunohistochemical pattern was also observed in undifferentiated carcinomas () (b), with clinical history of lymph nodal metastases (N+) () (c), and with worse prognosis () (d). Cytoplasmic delocalization with loss of beta-catenin was, generally, reported in oropharyngeal carcinomas and cheek cancer () (e), in Italian patients () (f).