Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit

Table 1

Biochemical tests of haloperidol- (HA-) intoxicated rabbits receiving various doses of intravenous lipid emulsion (ILE) or normal saline, 24 hours after starting HA or AWD infusion. Data are reported in means ± standard error.

Lab test; (unite)	ADW + normal saline 18 mL/kg	ADW + 18 mL/Kg; ILE	HA + normal saline 18 mL/kg	HA + ILE 6 mL/kg	HA + ILE 12 mL/kg	HA + ILE 18 mL/kg
Blood urea nitrogen (mg/dL)	16 ± 1.68	18.0 ± 2.55	29.0 ± 8.45**	18.2 ± 3.11	23.4 ± 12.66	40.3 ± 18.52*
Serum creatinine; (mg/dL)	1.16 ± 0.007	1.1 ± 0.063	1.82 ± 0.57	1.08 ± 0.08	1.14 ± 0.144	1.5 ± 0.141
Alanine transaminase; (IU/L)	61.0 ± 5.1	62.5 ± 11.6	54.0 ± 13.4	57.3 ± 8.8	86.5 ± 4.6*	83.0 ± 8.5*
Aspartate transaminase; (IU/L)	39.3 ± 6.3	67.8 ± 19.8	130.8 ± 63.5	42.5 ± 4.6	82.3 ± 29.8	314.0 ± 64.6*
Alkaline Phosphatase; (IU/L)	243.5 ± 57.56	153.5 ± 38.86	379.5 ± 49.46	293.75 ± 23.83	342.2 ± 59.63	388.5 ± 48.5
Amylase (U/L)	274.4 ± 13.12	226.2 ± 29.05	234.6 ± 24.44	214 ± 19.20	269 ± 26.21	443.0 ± 120.9
Lipase (U/L)	215.5 ± 25.83	128.75 ± 33.62	147.0 ± 27.66	162.25 ± 42.13	226.5 ± 43.51	495.0 ± 228.5

^∗𝑃<0.05,^∗∗𝑃<0.01, ADW: aseptic distilled water.