Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation

Figure 1

Experimental design. C57BL/6 pregnant mice were exposed from 5 days before delivery until 5 days after birth either to normoxia, hypoxia, or hypoxia with simultaneous administration of inhaled NO (iNO). Pups were then raised in normoxia until adulthood. Mice were studied as young adults (5-6 months) or old adults (12–15 months).