Research Article

Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel

Table 3

Genes that exhibit unique fold changes in animals in SED and EX groups, for SED and EX, 16 mo versus 3 mo.

Gene symbolGene nameGene functionFold change SEDFold change EX

myoc Myocilin, trabecular meshwork inducible glucocorticoid responseCytoskeletal function and is expressed in many occular tissues1.7#

fn1 Fibronectin 1Involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape−1.5*

s100a10 S100 calcium binding protein A10Regulator of protein phosphorylation, involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation−1.5*

lgals3 Lectin, galactoside-binding, soluble, 3Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells−1.6*

il33 Interleukin 33Induces T-helper type 2-associated cytokines1.6#

vcan VersicanMay play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth, and differentiation. Binds hyaluronic acid.−1.6*

emp1 Epithelial membrane protein 1−1.5*

nr1d1 Nuclear receptor subfamily 1, group D, member 1−1.5*

ncam1 Neural cellular adhesion moleculeCell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, and outgrowth of neurites1.6#

fhl3 Four and a half LIM domains 3May be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression−1.6*

nr0b2 nuclear receptor subfamily 0, group B, member 1Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis−1.5*

ptgfr Prostaglandin F receptorReceptor for prostaglandin F2-alpha (PGF2alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum1.8#

xpnpep2 Inhibin alphaHypothalamic, pituitary, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development, or bone growth1.5#

abca1 Cholinergic receptor, nicotinic, alpha 1Plays a role in acetylcholine binding/channel gating1.5#

pla2g2a Cytochrome P450, family 1, subfamily A polypeptide 1Drug metabolism and synthesis of cholesterol, steroids, and other lipids, involved in an NADPH-dependent electron transport pathway−1.7*

: upregulation; *: downregulation.