Endometrial Receptivity Profile in Patients with Premature Progesterone Elevation on the Day of hCG Administration

Table 1

Design of three microarray-based studies that investigated the impact of high serum progesterone level on the endometrial gene expression profile.

Study	Study population	Number of patients	Number of samples	Sampling time	[P] cutt-off (ng/mL)	Compared samples		Fold change	Number of genes
									Up	Down
[22]	Oocyte donors	12	12	hCG+7	1.5	hCG+7, [P] > 1.5 versus hCG+7, [P] < 1.5		≥2	64	76
						(𝑛=6)	(𝑛=6)
[23]	Patients undergoing IVF due to tubal or male infertility	10	10	hCG+8	1.2, 1.9	hCG+8, [P] < 1.2 versus hCG+8, [P] > 1.9		≥2	13	9
						(𝑛=5)	( (𝑛=5)
[27]	Not specified	14	14	hCG+2	1, 1.5	hCG+2, [P] ≤ 0.9 versus hCG+2, 1 > [P] > 1.5		≥1.4	5*	23*
						(𝑛=3)	( (𝑛=6)
						hCG+2, 1 > [P] > 1.5 versus hCG+2, [P] > 1.5			607*	212*
						(𝑛=6)	( (𝑛=5)
This study	Normoovulatory women referred for ICSI	15	30	hCG+2, hCG+5	1.5	hCG+2 [P] < 1.5 versus hCG+5 [P] < 1.5		>2	877	600
						(𝑛=7)	( (𝑛=7)
						hCG+2 [P] > 1.5 versus hCG+5 [P] > 1.5			123	110
						(𝑛=8)	( (𝑛=8)

∗Data are expressed in number of probe sets; 𝑛: number of samples; ICSI: intracytoplasmic sperm injection.