MicroRNAs: Novel Players in Cancer Diagnosis and Therapies

Table 1

miRNAs explored as potential cancer therapeutic agents.

miR	Cancer type	Targets
let-7a	Breast [24], endometrial [40]	HER2 and aurora-B
miR-15 and miR-16	Leukemia [32]	Bcl-2
miR-21	Glioblastoma, breast [41]	E-cadherin-ZEB1/2 pathway
miR-21 and miR-181b	Glioma [42]	FOS
miR-22 and miR-200b	Gastric [43]	Wnt-1 pathway
miR-26a	Liver, prostate, skin [44], bladder [45]	Lin28B, Zcchc11, and HMGA1
miR-27a	Lung [22], breast [46]	MET, EGFR, and PI3K-AKT pathway
miR-27b	Colorectal [47]	VEGFC
miR-29a	Osteosarcoma [27]	Bcl-2, Mcl-1
miR-31	Colorectal [36]	RASA1
miR-34	Breast (34a) [23], pancreatic [30], lung [35], lung (34a, c) [48]	AXL, Bcl-2, K-Ras, and PDGFR-α/β
miR-99a	Lung [21]	mTOR/FGFR3
miR-106b-5p	Glioma [49]	RBL1, RBL2, and CASP8
miR-122	Liver [33]	Bcl-w
miR-130b	Pancreatic [50]	STAT3
miR-133a	Osteosarcoma [28]	Bcl-xL and Mcl-1
miR-138	Glioblastoma [51]	EZH2-CDK4/6-pRb-E2F1 pathway
miR-145	Ovarian [52]	p70S6K1 and MUC1
miR-148a	Colorectal [31], liver [53]	Bcl-2 and Met/Snail pathway
miR-150	Lung [54]	p53
miR-155	Breast [46, 55, 56]	VHL, TP53INP1, and PI3K-AKT pathway
miR-181	Squamous cell (181a) [37], breast [57]	K-Ras and ataxia telangiectasia mutated (ATM)
miR-185 and miR-342	Prostate [58]	SREBP pathway
miR-193a-3p	Glioblastoma [26]	Mcl-1
miR-205	Oral [59]	Axin 2
miR-210	Hypoxic conditions [20]	Ephrin-A3
miR-219-5p	Glioblastoma [25]	EGFR
miR-221	Pancreatic [60], breast [61]	PTEN, p27kip1, p57kip2, and PUMA
miR-301a	Breast [62]	PTEN
miR-449a and -449b	Retinoblastoma [63]	E2F transcription factors
miR-451	Lung [39]	RAB14
miR-491-5p	Pancreatic [29]	TP53 and Bcl-xL
miR-494	Glioma [64]	p190B RhoGAP
miR-497	Neuroblastoma [65]	WEE1
miR-636	Liver [38]	Ras
miR-708	Bladder [66]	Caspase-2