Review Article

MicroRNAs: Novel Players in Cancer Diagnosis and Therapies

Table 2

miRNAs in combination with traditional cancer therapies.

miRCancer type (effect of expression on treatment)Treatments investigated

let-7aLeukemia [67] (sensitive), breast [68, 69] (sensitive), pancreatic [70] (sensitive)Ara-C, irradiation, paclitaxel, gemcitabine
let-7bGlioblastoma [71] (sensitive)Cisplatin
let-7cEsophageal [72] (sensitive)Cisplatin
let-7eOvarian [73] (sensitive)Cisplatin
miR-9Glioblastoma [74] (resistant)Temozolomide
miR-10bColon [75] (resistant)Fluorouracil
miR-15bTongue [76] (sensitive)Gemcitabine
miR-17-5pPancreatic [77] (resistant)Gemcitabine
miR-19aBreast [6] (resistant)Taxol, mitoxantrone, etoposide
miR-21Gastric [7] (resistant), pancreatic [7880] (resistant), glioblastoma [8184] (resistant), colorectal [85, 86] (resistant), adenocarcinoma [87] (resistant)Gemcitabine, fluorouracil, temozolomide, irradiation, cisplatin
miR-23bPancreatic [88] (sensitive)Irradiation
miR-29cNasopharynx [89] (sensitive)Cisplatin, irradiation
miR-30cBreast [90] (sensitive)Paclitaxel, doxorubicin
miR-30d, miR-181a and miR-199a-5pColorectal, prostate, and leukemia [91] (sensitive)Trichostatin A
miR-31Ovarian [92] (sensitive)Paclitaxel
miR-34aBreast [93] (sensitive), prostate [94] (sensitive), gastric [95] (miR-34c-5p, sensitive)Adriamycin, camptothecin, paclitaxel
miR-92bLung [9] (resistant)Cisplatin
miR-93Ovarian [5] (resistant)Cisplatin
miR-103 and miR-107Osteosarcoma, cervical, lung [96] (sensitive)AZD2281, cisplatin, etoposide, camptothecin, irradiation
miR-106aOvarian [97, 98] (sensitive or resistant)Cisplatin, paclitaxel
miR-125bBreast [99101] (resistant), Ewing sarcoma [102] (sensitive)Paclitaxel, fluorouracil, doxorubicin, gemcitabine
miR-128-2Lung [103] (resistant)Cisplatin, doxorubicin, fluorouracil
miR-130aLiver [104] (resistant)Cisplatin
miR-140Osteosarcoma and colon [105] (resistant)Fluorouracil
miR-141Ovarian [106] (resistant)Cisplatin
miR-143 and miR-145Colon [107] (sensitive)Fluorouracil, irinotecan, oxaliplatin
miR-145Glioblastoma [108] (sensitive), cervical [109] (sensitive)Irradiation, temozolomide, mitomycin
miR-152 and miR-185Ovarian [110] (sensitive)Cisplatin
miR-181bPancreatic [111, 112] (sensitive or resistant), glioblastoma [113] (sensitive)Gemcitabine, temozolomide
miR-182Ovarian [114] (resistant)Paclitaxel, cisplatin
miR-199a-5pLiver [115] (sensitive)Cisplatin
miR-200bPancreatic [80] (sensitive), tongue [75] (sensitive)Gemcitabine, cisplatin
miR-200cPancreatic [80] (sensitive), breast [116] (sensitive), ovarian [117] (sensitive)Gemcitabine, paclitaxel, doxorubicin
miR-223Liver [118] (sensitive)Doxorubicin, paclitaxel
miR-298Breast [119] (sensitive)Doxorubicin
miR-302Breast [120] (sensitive)Irradiation
miR-320Prostate [121] (sensitive), pancreatic [122] (miR-320c, resistant)Cisplatin, carboplatin, paclitaxel, gemcitabine
miR-375Gastric [11] (resistant), cervical [123] (resistant)Irradiation, etoposide, paclitaxel
miR-591Ovarian [97] (sensitive)Paclitaxel
miR-650Lung [124] (resistant)Docetaxel
miR-663Breast [125] (resistant)Adriamycin, chlorophosphamide, docetaxel
miR-708Ewing sarcoma [126] (sensitive)Etoposide, doxorubicin