The Laboratory of Genetics and Physiology 2: Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor

Table 1

RLR ligands and viruses reported to associate with each RLR.

Viral nucleic acid features (PAMPs)		ATP binding sites	Role in antiviral immune response	Viruses
LGP2	dsRNA, ssRNA, and free 5′-triphosphate end structures	446, 467, 471, 473	Positive	Encephalomyocarditis, vaccinia,and mengo
			Negative	Paramyxovirus Sendai, vesicular stomatitis, Newcastle disease, and influenza A
RIG-I	Short dsRNAs (<1 kb), free 5′-triphosphate end structures, and complex secondary RNA structures	271~276	Positive	Reovirus, dengue, West Nile, rotavirus, Sendai, Vesicular stomatitis, respiratory syncytial, measles, rabies; influenza A, influenza B, ebola, hepatitis C, Japanese encephalitis, and Newcastle disease
MDA-5	Long dsRNAs (>1 kb), ‘‘non-self-’’ RNA 5′-termini	332~426	Positive	Reovirus, dengue, West Nile, rotavirus, Sendai, encephalomyocarditis, mengo, Theiler, polio, and murine norovirus