Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 960575, 10 pages
http://dx.doi.org/10.1155/2014/960575
Research Article

Risk Factors for Hospital and Long-Term Mortality of Critically Ill Elderly Patients Admitted to an Intensive Care Unit

1Division of Respiratory and Critical Care Medicine, University Medicine Cluster, National University Health System, Singapore
2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
3Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
4The University of Sheffield, Sheffield, UK
5National University of Singapore, Singapore

Received 15 February 2014; Accepted 26 September 2014; Published 16 December 2014

Academic Editor: Anastasia Kotanidou

Copyright © 2014 A. Mukhopadhyay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Department of Economic and Social Affairs and United Nations Population Division, World Population Ageing 1950–2050, United Nations, New York, NY, USA, 2012.
  2. A. Boumendil, D. Somme, M. Garrouste-Orgeas, and B. Guidet, “Should elderly patients be admitted to the intensive care unit?” Intensive Care Medicine, vol. 33, no. 7, pp. 1252–1262, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. “Population trend 2012,” Department of Statistics, Singapore, http://www.singstat.gov.sg/.
  4. R. A. Mularski and M. L. Osborne, “End-of-life care in the critically ill geriatric population,” Critical Care Clinics, vol. 19, no. 4, pp. 789–810, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. D. C. Angus, A. E. Barnato, W. T. Linde-Zwirble et al., “Use of intensive care at the end of life in the United States: an epidemiologic study,” Critical Care Medicine, vol. 32, no. 3, pp. 638–643, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. D. C. Angus, M. A. Kelley, R. J. Schmitz, A. White, and J. Popovich Jr., “Current and projected workforce requirements for care of the critically III and patients with pulmonary disease: can we meet the requirements of an aging population?” Journal of the American Medical Association, vol. 284, no. 21, pp. 2762–2770, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Hennessy, K. Juzwishin, D. Yergens, T. Noseworthy, and C. Doig, “Outcomes of elderly survivors of intensive care: a review of the literature,” Chest, vol. 127, no. 5, pp. 1764–1774, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Sacanella, J. M. Pérez-Castejón, J. M. Nicolás et al., “Mortality in healthy elderly patients after ICU admission,” Intensive Care Medicine, vol. 35, no. 3, pp. 550–555, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Wunsch, C. Guerra, A. E. Barnato, D. C. Angus, G. Li, and W. T. Linde-Zwirble, “Three-year outcomes for medicare beneficiaries who survive intensive care,” The Journal of the American Medical Association, vol. 303, no. 9, pp. 849–856, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Boumendil, P. Aegerter, and B. Guidet, “Treatment intensity and outcome of patients aged 80 and older in intensive care units: a Multicenter Matched-Cohort Study,” Journal of the American Geriatrics Society, vol. 53, no. 1, pp. 88–93, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. O. H. Torres, E. Francia, V. Longobardi, I. Gich, S. Benito, and D. Ruiz, “Short- and long-term outcomes of older patients in intermediate care units,” Intensive Care Medicine, vol. 32, no. 7, pp. 1052–1059, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Bo, M. Massaia, S. Raspo et al., “Predictive factors of in-hospital mortality in older patients admitted to a medical intensive care unit,” Journal of the American Geriatrics Society, vol. 51, no. 4, pp. 529–533, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Rockwood, T. W. Noseworthy, R. T. N. Gibney et al., “One-year outcome of elderly and young patients admitted to intensive care units,” Critical Care Medicine, vol. 21, no. 5, pp. 687–691, 1993. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Lemeshow, D. Teres, J. Klar, J. S. Avrunin, S. H. Gehlbach, and J. Rapoport, “Mortality probability models (MPM II) based on an international cohort of intensive care unit patients,” The Journal of the American Medical Association, vol. 270, no. 20, pp. 2478–2486, 1993. View at Publisher · View at Google Scholar · View at Scopus
  15. B.-C. Tai, R. G. Grundy, and D. Machin, “On the importance of accounting for competing risks in pediatric cancer trials designed to delay or avoid radiotherapy: I. Basic concepts and first analyses,” International Journal of Radiation Oncology, Biology, Physics, vol. 76, no. 5, pp. 1493–1499, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. B.-C. Tai, R. Grundy, and D. MacHin, “On the importance of accounting for competing risks in pediatric brain cancer: II. Regression modeling and sample size,” International Journal of Radiation Oncology Biology Physics, vol. 79, no. 4, pp. 1139–1146, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. W. A. Knaus, E. A. Draper, D. P. Wagner, and J. E. Zimmerman, “APACHE II: a severity of disease classification system,” Critical Care Medicine, vol. 13, no. 10, pp. 818–829, 1985. View at Publisher · View at Google Scholar · View at Scopus
  18. W. A. Knaus, D. P. Wagner, E. A. Draper et al., “The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults,” Chest, vol. 100, no. 6, pp. 1619–1636, 1991. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Somme, J.-M. Maillet, M. Gisselbrecht, A. Novara, C. Ract, and J.-Y. Fagon, “Critically ill old and the oldest-old patients in intensive care: short- and long-term outcomes,” Intensive Care Medicine, vol. 29, no. 12, pp. 2137–2143, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Minne, J. Ludikhuize, E. de Jonge, S. de Rooij, and A. Abu-Hanna, “Prognostic models for predicting mortality in elderly ICU patients: a systematic review,” Intensive Care Medicine, vol. 37, no. 8, pp. 1258–1268, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. R. M. Kleinpell and C. E. Ferrans, “Factors influencing intensive care unit survival for critically ill elderly patients,” Heart and Lung: Journal of Acute and Critical Care, vol. 27, no. 5, pp. 337–343, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. D. M. Nierman, C. B. Schechter, L. M. Cannon, and D. E. Meier, “Outcome prediction model for very elderly critically ill patients,” Critical Care Medicine, vol. 29, no. 10, pp. 1853–1859, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. N. I. Lone and T. S. Walsh, “Impact of intensive care unit organ failures on mortality during the five years after a critical illness,” The American Journal of Respiratory and Critical Care Medicine, vol. 186, no. 7, pp. 640–647, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Ai-Ping, K.-H. Lee, and T.-K. Lim, “In-hospital and 5-year mortality of patients treated in the ICU for acute exacerbation of COPD: a retrospective study,” Chest, vol. 128, no. 2, pp. 518–524, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Garrouste-Orgeas, A. Boumendil, D. Pateron et al., “Selection of intensive care unit admission criteria for patients aged 80 years and over and compliance of emergency and intensive care unit physicians with the selected criteria: an observational, multicenter, prospective study,” Critical Care Medicine, vol. 37, no. 11, pp. 2919–2928, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M. B. Hamel, J. Lynn, J. M. Teno et al., “Age-related differences in care preferences, treatment decisions, and clinical outcomes of seriously ill hospitalized adults: lessons from SUPPORT,” Journal of the American Geriatrics Society, vol. 48, no. 5, pp. S176–S182, 2000. View at Google Scholar · View at Scopus
  27. B.-C. Tai, D. Machin, I. White, and V. Gebski, “Competing risks analysis of patients with osteosarcoma: a comparison of four different approaches,” Statistics in Medicine, vol. 20, no. 5, pp. 661–684, 2001. View at Publisher · View at Google Scholar · View at Scopus