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BioMed Research International
Volume 2014, Article ID 962903, 20 pages
Review Article

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

1Faculty of Biosciences and Medical Engineering (FBME), Universiti Teknologi Malaysia, Building VO1, Block A, Level 5, Room 27, 81310 Skudai, Johor, Malaysia
2Faculty of Mechanical Engineering (FKM), Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia

Received 28 February 2014; Revised 16 July 2014; Accepted 11 August 2014; Published 8 September 2014

Academic Editor: Michael Kalafatis

Copyright © 2014 Radha S. P. Malon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.