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BioMed Research International
Volume 2014, Article ID 962915, 8 pages
Review Article

Commentary on the Regulation of Viral Proteins in Autophagy Process

1Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan
2Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan
3Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan

Received 14 December 2013; Accepted 4 February 2014; Published 10 March 2014

Academic Editor: Wei-Li Hsu

Copyright © 2014 Ching-Yuan Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The ability to subvert intracellular antiviral defenses is necessary for virus to survive as its replication occurs only in the host cells. Viruses have to modulate cellular processes and antiviral mechanisms to their own advantage during the entire virus life cycle. Autophagy plays important roles in cell regulation. Its function is not only to catabolize aggregate proteins and damaged organelles for recycling but also to serve as innate immunity to remove intracellular pathogenic elements such as viruses. Nevertheless, some viruses have evolved to negatively regulate autophagy by inhibiting its formation. Even more, some viruses have employed autophagy to benefit their replication. To date, there are more and more growing evidences uncovering the functions of many viral proteins to regulate autophagy through different cellular pathways. In this review, we will discuss the relationship between viruses and autophagy and summarize the current knowledge on the functions of viral proteins contributing to affect autophagy process.