Human Serum Albumin Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN38) for Cancer Treatment

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Sample</td><td align="center">IC<sub>50</sub> (<svg height="12.175" id="M70" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.5625 12.175" width="9.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q-7 -33 0 -55t25 -22q36 0 105.5 75t107.5 145l32 146l75 26h10q-50 -197 -78 -347q-7 -38 6 -38q7 0 31 17t47 39z" id="x1D707"></path></g>
</svg>M)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Free SN38</td><td align="center"><span style="width: 82.525002px;"><svg height="11.2875" id="M71" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 82.525002 11.2875" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td></tr><tr><td align="left">SN38-HSA-15</td><td align="center"><span style="width: 82.525002px;"><svg height="11.2875" id="M72" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 82.525002 11.2875" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td></tr><tr><td align="left">SN38-HSA-60</td><td align="center"><span style="width: 82.525002px;"><svg height="11.2875" id="M73" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 82.525002 11.2875" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td></tr><tr><td align="left">Irinotecan</td><td align="center"><span style="width: 90.6875px;"><svg height="11.2875" id="M74" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 90.6875 11.2875" width="90.6875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

IC<sub>50</sub> values of free SN38 and SN38-HSA conjugates on HT-29 cell line within 48<b> </b>h of incubation.

BioMed Research International

tab2

Table 2

Table 2: Human Serum Albumin Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN38) for Cancer Treatment 