Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers
Figure 3
Injection-induced droplet-to-bubble transition. (a) Nanodroplets inserted in PBS through an 18 G needle or 26 G needle. Bubbles formed when nanoemulsion was injected through a thin needle are seen as bright spots (indicated by arrows in the right panel); bubbles rise to the surface while droplets precipitate to the bottom of a test tube. (b) Nanodroplets injected in the agarose gel 18 G (left) or 26 G (right) needles. Injection through the 18 G needle leads to very bright bubbles instantly, whose brightness and size increase over time; the increased brightness of the droplets with time suggesting a droplet-to-bubble transition [20].
