Female Aging Alters Expression of Human Cumulus Cells Genes that Are Essential for Oocyte Quality
Figure 1
(a) Expression of cumulus cells genes according to female age. Box-and-whisker plots that represent expression of genes implicated in different biological processes and signaling pathways in the three female age categories, , CCmedian, and CColder. The signal intensity of each gene is shown on the axis as arbitrary units determined by the Affymetrix GCOS software. (b) Heat map and cluster dendograms of differentially expressed genes. Hierarchical clustering is shown for 20 genes with the highest expression level in each of the 3 age categories of individual CCs. Overexpressed and underexpressed genes were marked in blue and pink, respectively. The three age categories are shown in white for , grey for , and black for .
