Research Article
Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
Table 2
Prevalence of MDR1 genotypes among pesticide-exposed fruit growers and controls.
| | MDR1 genotypes | | Controls | Pesticide exposure | value | | Low | High |
| | Number of subjects | | 141 | 82 | 113 | | | C3435T | CC | 64 (45.4%) | 29 (35.4%) | 47 (41.6%) | | | (rs1045642) | CT | 56 (39.7%) | 40 (48.8%) | 46 (40.7%) | | | | TT | 21 (14.9%) | 13 (15.8%) | 20 (17.7%) | | | C1236T | CC | 22 (15.6%) | 12 (14.6%) | 12 (10.6%) | | | (rs1128503) | CT | 59 (41.8%) | 33 (40.3%) | 54 (47.8%) | | | | TT | 60 (42.6%) | 37 (45.1%) | 47 (41.6%) | | | G2677T/A | GG | 36 (25.5%) | 23 (28.1%) | 30 (26.5%) | | | (rs2032582) | GT/GA | 54 (38.3%) | 36 (43.9%) | 48 (42.5%) | | | | TA/TT/AA | 51 (36.2%) | 23 (28.0%) | 35 (31.0%) | | | | Non-GG | 105 (74.5%) | 59 (71.9%) | 83 (73.5%) | 0.92 | | T-129C | TT | 120 (85.1%) | 72 (87.8%) | 102 (90.3%) | 0.72* | | (rs3213619) | TC | 15 (10.6%) | 8 (9.8%) | 9 (8.0%) | | | | CC | 6 (4.3%) | 2 (2.4%) | 2 (1.8%) | | | | TC/CC | 21 (14.9%) | 10 (12.2%) | 11 (9.7%) | 0.46 |
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Frequencies of T-129C genotype among the groups of low and high pesticide exposure and controls were compared by Fisher exact test.
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