Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
Table 3
Average tail moment per cell stratified by pesticide exposure status and various factors.
Controls
Pesticide exposure
Variables
Low
High
Mean ± SE
Mean ± SE
Mean ± SE
All
141
82
113
Age (years)
≥53
44
46
60
<53
97
36
53
Gender
Males
68
47
84
Females
73
Smoking status
>10 pack-years
19
21
≤10 pack-years
122
61
MDR1 C3435T genotype
CC
64
29
47
CT
56
40
46
TT
21
13
20
MDR1 C1236T genotype
CC
22
12
12
CT
59
33
54
TT
60
37
47
MDR1 G2677T/A genotype
GG
36
23
30
GT/GA
54
36
48
TA/TT/AA
51
23
35
Non-GG
105
60
83
MDR1 T-129C genotype
TT
120
72
102
TC
15
8
9
CC
6
2
2
TC/CC
21
10
11
Comparisons among different pesticide-exposed status groups or (three) genotype groups conducted with ANOVA; comparisons between age, gender, smoking status, and (two) genotype groups conducted with -test.
*
.
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