Reference number Cell source Culture/duration Cell number/processing Growth factor level [7 ] Hu-ESC-EC Monolayer —5 days NA
Angiogenic cytokine: VEGF, SDF-1, PlGF, leptin, EGF, bFGF, and HGF: CM DM-PAC < CM cPAC Angiogenic cytokine: VEGF, PDGF, ICAM-1, EGF, and bFGF: CM ESC-EC > CM c-PAC = CM D-PAC
[13 ] (i) Hu-ESC-CD133/KDR-EPC (ii) Hu-UCB-EPC Monolayer—48 hours 80% in 150 mm culture dish/Conc. 50x EGF ESC-EPC versus CB-EPC versus EGM-2 12584 versus 12654 versus 9 pg/mL FGF-2 383 versus 652 versus 61 Fractalkine 1605 versus 150 versus 133 GM-CSF 755 versus 323 versus 313 IL-6 4332 versus 1961 versus 2463 IL-8 239030 versus 13629 versus 7 IL-9 345 versus 42 versus 9 IP-10 458 versus 513 versus 511 MCP-1 63 versus 3201 versus 1902 PDGF-AA 6667 versus 5568 versus 41 PDGF-AB/BB 17 versus 1884 versus 75 VEGF 4265 versus 538 versus 42
[9 ] Hu-AF SC—Ckit (+) Monolayer—16 hours 15 × 104 —70%/from 5 × 105 cells Conc. 12.5x VEGF, IL-8, SDF-1 1 ng/170.000 cell (1 g DNA) IL-6, MCP-1 0.5 ng/170.000 cell TGF-b 0.2 ng/170.000 cell IFNg — IP-10 /CXCL10 — IL-1a — [20 ] (i) Hu-AF-MSC (ii) Hu-AF-MSC-HPL Monolayer—24 hours 1.5 × 106 80%/ Conc. 25x
Proteome analysisHu-AF-MSC-HPL-CM : Anti-inflammatory cytokine: IL-10, IL-27, IL-17E, IL-13, IL-12p70, and IL-1ra Liver protection: MCP- 1, IL-1bHu-AF-MSC-HPL-CM, AF-MSC-CM : Anti-inflammatory cytokine: TGFβ 1 Tissue repair: serpin E1, SDF-1 Angiogenesis: VEGF, PDEGF, and endostatin/collagen XVIII Liver regeneration: UPA, thrombospondin 1 and 2, HEGF, FGF-7, EGF, and HGF Anti-apoptotic markers: TIMP-1, IGFBP
[8 ] (i) Hu-PB-MNC- EPC (ii) HUVEC Monolayer—72 hours NA IL-8/CXCL8 Hypox versus norm 29090.7 ± 12279.4 pg/mL versus 2282.1 ± 406.3 pg/mL SDF-1/CXCL12 6059.9 ± 654.6 pg/mL versus 3179.9 ± 488.0 pg/mL HGF 539.5 ± 141.7 pg/mL versus 343.4 ± 74.8 pg/mL Angiogenin 144.6 ± 68.2 pg/mL versus 72.5 ± 15.8 pg/mL PDGF-BB 111.6 ± 27.02 pg/mL versus 19.9 ± 2.2 pg/mL VEGF-A 25.5 ± 4.8 pg/mL versus 11.4 ± 5.2 pg/mL
[10 ] Hu-UCB SC (endothelial + MSC) Monolayer—48 hours 80%/Conc. 50x EGF 3,286 ± 419 pg/mL VEGF 2,463 ± 151 pg/mL G-CSF 3,615 ± 173 pg/mL GM-CSF 3,623 ± 345 pg/mL TGF-β 1, PDGF, bFGF, and KGF =HUVEC HUVEC Monolayer—48 hours 80%/Conc. 50x EGF UCB-SC-4.8X VEGF UCB-SC-42x G-CSF UCB-SC-3.7x GM-CSF UCB-SC-2.4x [22 ] Hu-BM-MSC Monolayer—24 hours 2 × 106 /Conc. 25x
69 from 174 prot. tested (+) (concentration NA) [27 ] Hu-BM-MSC Monolayer—24 hours 4 × 106 /Conc. 25x VEGF HGF Normoxia: 230 pg/mL Hypoxia: 450 pg/mL Normoxia: 600 pg/mL Hypoxia: 750 pg/mL
[17 ] Hu-BM-MNC-stro-3-MPC NA 1 × 106 /Conc. IL-6 = 2x C 118.04 ± 0.27 pg/mL MCP-1 = 2x C 521.89 ± 1.48 pg/mL VEGF = 2x C 33.95 ± 2.98 pg/mL
[25 ] (i) Hu-BM-MSC (ii) Hu-BM-CD133 (iii) Hu-BM-p75 Monolayer—48 hours 1 × 106 90%/ Conc. 40x Secretion/cell P75 versus CD133 versus BMMSC IL6—norm 3.8 versus 0.8 versus 0.6 fg IL6—hypox 0.25 = 0.25 versus 0.1 fg PlGF—norm 0.045 versus 0.01 versus 0 fg PlGF—hypox 0.043 versus 0.025 versus 0.15 fg ADM—norm 0.1 versus 0.05 versus 0.2 fg ADM—hypox 5.8 versus 5.4 versus 11.5 fg VEGF—norm 1.5 versus 1.0 versus 1.35 fg VEGF—hypox 0.7 versus 0.9 versus 0.95 fg SDF-1—norm 1.35 versus 0.75 versus 0.15 fg SDF-1—hypox 0.4 versus 0.7 versus 1.0 fg HGF—norm 0.84 versus 0.7 versus 0.25 fg HGF—hypox 0.01 versus 0.25 versus 0.01 fg DKK-I—norm 4 versus 4 versus 4.5 fg DKK-1—hypox 6.8 versus 6.5 versus 10.5 fg
[28 ] Rat-BM-MSC Monolayer—48 hours 90% T75/Conc. 40x
23 from 90 prot. tested (+) NGF 356 ± 117 pg/mL BDNF 208 ± 57 pg/mL IL-6 427± 168 pg/mL
[24 ] Hu-AD-MSC Spheroid—2 days 4.2 × 107 /Centr. CM versus αMEM:hTGF-b1 14.33 ± 6.71 versus 2.49 ± 2.39 pg/mL hVEGF 1,015.17 ± 170.97 pg/mL versus ND hPDGF-AA Both ND
[6 ] Hu-AD-SC In MEM—FBS Spheroid—2 days 105 /Centr. VEGF 14.4 ± 0.4 ng/mL FGF2 13.2 ± 2.2 ng/mL HGF 13.3 ± 2.3 ng/mL CXCL12 16.6 ± 2.9 ng/mL In CRM-hu allo No diff >< MEM-FBS In CRM-serum (−) GF < In αMEM—FBS
Monolayer—2 days
105 /Centr. GF<<< In CRM-hu allo GF<<<
[5 ] Hu-AD-SC Monolayer— 72 hours 4 × 105 /Conc. Spot density array hypox versus nomoxia GCSF 14.07 ± 3.84 versus 10.13 ± 4.21 GM-CSF 13.53 ± 1.26 versus 10.21 ± 1.44 IGFBP-1 9.48 ± 0.44 versus 5.56 ± 0.44 IGFBP-2 8.91 ± 0.02 versus 6.73 ± 0.31 IGF-II 10.62 ± 0.85 versus 4.61 ± 0.93 M-CSF 14.06 ± 0.13 versus 7.46 ± 1.69 M-CSF R 9.09 ± 0.20 versus 3.31 ± 1.75 PDGF Rβ 17.67 ± 1.32 versus 11.47 ± 1.40 PDGF-AA 16.63 ± 1.33 versus 12.14 ± 2.12 VEGF 13.47 ± 1.26 versus 5.59 ± 1.22 EGF 11.06 ± 2.45 versus 34.14 ± 6.75
[36 ] (i) AD-SC (ii) Hu dermal fibroblast NA NA AD-SC VEGF 810.65 ± 56.92 pg/ g DNA IGF-I 328.33 ± 22.7 pg/ g DNA Hu dermal fibroblast VEGF 28.4 ± 2.25 pg/ g DNA IGFI Undetectable
[33 ] Hu-MSC (Lonza) Monolayer—48 hours 70%/(—) IGF-1 1515.6 ± 211.8 pg/mL VEGF 465.8 ± 108.8 pg/mL TGF-b1 339.8 ± 14.4 pg/mL HGF 20.3 ± 7.9 pg/mL, FGF-2, PDGFBB, BMP-2, and SDF-1 (—)