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BioMed Research International
Volume 2014, Article ID 968495, 6 pages
http://dx.doi.org/10.1155/2014/968495
Research Article

Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants

1Institute of Anatomy “NikoMiljanić”, Medical Faculty, Dr Subotića 4, University of Belgrade, Belgrade, Serbia
2Clinic of Dental Prosthetic, The Faculty of Stomatology, University of Belgrade, Serbia
3Institute for Statistics, Faculty of Organizational Sciences, University of Belgrade, Serbia
4Institute for Traumatology, Emergency Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia
5Institute for Psychiatry, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Serbia

Received 8 December 2013; Revised 12 February 2014; Accepted 13 February 2014; Published 13 March 2014

Academic Editor: Igor Jakovcevski

Copyright © 2014 Ana Starcevic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Toomey, H. K. Kang, J. Karlinsky et al., “Mental health of US Gulf War veterans 10 years after the war,” British Journal of Psychiatry, vol. 190, pp. 385–393, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. J. Nutt and A. L. Malizia, “Structural and functional brain changes in posttraumatic stress disorder,” Journal of Clinical Psychiatry, vol. 65, supplement 1, pp. 11–17, 2004. View at Google Scholar · View at Scopus
  3. M. van Ommeren, B. Sharma, G. K. Sharma, I. Komproe, E. Cardeña, and J. T. V. M. de Jong, “The relationship between somatic and PTSD symptoms among Bhutanese refugee torture survivors: examination of comorbidity with anxiety and depression,” Journal of Traumatic Stress, vol. 15, no. 5, pp. 415–421, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. G. J. G. Asmundson, M. J. Coons, S. Taylor, and J. Katz, “PTSD and the experience of pain: research and clinical implications of shared vulnerability and mutual maintenance models,” Canadian Journal of Psychiatry, vol. 47, no. 10, pp. 930–937, 2002. View at Google Scholar · View at Scopus
  5. R. de Leeuw, J. E. Schmidt, and C. R. Carlson, “Traumatic stressors and post-traumatic stress disorder symptoms in headache patients,” Headache, vol. 45, no. 10, pp. 1365–1374, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. G. de Benedittis and A. Lorenzetti, “The role of stressful life events in the persistence of primary headache: major events vs. daily hassles,” Pain, vol. 51, no. 1, pp. 35–42, 1992. View at Publisher · View at Google Scholar · View at Scopus
  7. S. K. Ficek and D. A. Wittrock, “Subjective stress and coping in recurrent tension-type headache,” Headache, vol. 35, no. 8, pp. 455–460, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Karl, M. Schaefer, L. S. Malta, D. Dörfel, N. Rohleder, and A. Werner, “A meta-analysis of structural brain abnormalities in PTSD,” Neuroscience and Biobehavioral Reviews, vol. 30, no. 7, pp. 1004–1031, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Kitayama, V. Vaccarino, M. Kutner, P. Weiss, and J. D. Bremner, “Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis,” Journal of Affective Disorders, vol. 88, no. 1, pp. 79–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. M. E. Smith, “Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies,” Hippocampus, vol. 15, no. 6, pp. 798–807, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. V. G. Carrion, C. F. Weems, S. Eliez et al., “Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder,” Biological Psychiatry, vol. 50, no. 12, pp. 943–951, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. M. D. de Bellis, M. S. Keshavan, H. Shifflett et al., “Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study,” Biological Psychiatry, vol. 52, no. 11, pp. 1066–1078, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Fennema-Notestine, M. B. Stein, C. M. Kennedy, S. L. Archibald, and T. L. Jernigan, “Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder,” Biological Psychiatry, vol. 52, no. 11, pp. 1089–1101, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. S. L. Rauch, L. M. Shin, E. Segal et al., “Selectively reduced regional cortical volumes in post-traumatic stress disorder,” NeuroReport, vol. 14, no. 7, pp. 913–916, 2003. View at Google Scholar · View at Scopus
  15. H. Yamasue, K. Kasai, A. Iwanami et al., “Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 15, pp. 9039–9043, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. S. H. Woodward, D. G. Kaloupek, C. C. Streeter, C. Martinez, M. Schaer, and S. Eliez, “Decreased anterior cingulate volume in combat-related PTSD,” Biological Psychiatry, vol. 59, no. 7, pp. 582–587, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Corbo, M.-H. Clément, J. L. Armony, J. C. Pruessner, and A. Brunet, “Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder,” Biological Psychiatry, vol. 58, no. 2, pp. 119–124, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Matsuoka, S. Yamawaki, M. Inagaki, T. Akechi, and Y. Uchitomi, “A volumetric study of amygdala in cancer survivors with intrusive recollections,” Biological Psychiatry, vol. 54, no. 7, pp. 736–743, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. B. R. Filipovic, B. M. Djurovic, S. Marinkovic et al., “Volume changes of corpus striatum, thalamus, hippocampus and lateral ventricles in posttraumatic stress disorder (PTSD) participants suffering from headaches and without therapy,” Central European Neurosurgery, vol. 71, pp. 1–5, 2011. View at Google Scholar
  20. M. Hamilton, “A rating scale for depression,” Journal of Neurology, Neurosurgery, and Psychiatry, vol. 23, pp. 56–62, 1960. View at Google Scholar · View at Scopus
  21. M. M. Ohayon, “Epidemiology of insomnia: what we know and what we still need to learn,” Sleep Medicine Reviews, vol. 6, no. 2, pp. 97–111, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. M. V. Sale, M. C. Ridding, and M. A. Nordstrom, “Cortisol inhibits neuroplasticity induction in human motor cortex,” Journal of Neuroscience, vol. 28, no. 33, pp. 8285–8293, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Patenaude, S. Smith, D. Kennedy et al., “Bayesian shape and appearance models,” FMRIB Technical Report TR07BP1, FMRIB, Oxford, UK, 2007. View at Google Scholar
  24. A. C. Evans, J. A. Frank, J. Antel, and D. H. Miller, “The role of MRI in clinical trials of multiple sclerosis: comparison of image processing techniques,” Annals of Neurology, vol. 41, no. 1, pp. 125–132, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. S. M. Smith, Y. Zhang, M. Jenkinson et al., “Accurate, robust, and automated longitudinal and cross-sectional brain change analysis,” NeuroImage, vol. 17, no. 1, pp. 479–489, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. B. L. Peterlin, S. S. Nijjar, and G. E. Tietjen, “Post-traumatic stress disorder and migraine: epidemiology, sex differences, and potential mechanisms,” Headache, vol. 51, no. 6, pp. 860–868, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Ahmed, J. Ras, and S. Seedat, “Volumetric structural magnetic resonance imaging findings in pediatric posttraumatic stress disorder and obsessive compulsive disorder: a systematic review,” Frontiers in Psychology, vol. 3, p. 568, 2012. View at Google Scholar
  28. T. V. Gurvits, M. E. Shenton, H. Hokama et al., “Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder,” Biological Psychiatry, vol. 40, no. 11, pp. 1091–1099, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. E. L. Wignall, J. M. Dickson, P. Vaughan et al., “Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder,” Biological Psychiatry, vol. 56, no. 11, pp. 832–836, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. F. L. Woon and D. W. Hedges, “Amygdala volume in adults with posttraumatic stress disorder: a meta-analysis,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 21, no. 1, pp. 5–12, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. M. A. Rogers, H. Yamasue, O. Abe et al., “Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder,” Psychiatry Research—Neuroimaging, vol. 174, no. 3, pp. 210–216, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. R. K. Lenroot and J. N. Giedd, “The structural and functional developmental trajectory of the frontal cortex,” Australian & New Zealand Journal of Psychiatry, vol. 44, p. A7, 2010. View at Google Scholar
  33. Y. Matsuoka, S. Yamawaki, M. Inagaki, T. Akechi, and Y. Uchitomi, “A volumetric study of amygdala in cancer survivors with intrusive recollections,” Biological Psychiatry, vol. 54, no. 7, pp. 736–743, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Etkin and T. D. Wager, “Functional neuroimaging of anxiety: a meta-ana lysis of emotional processing in PTSD, social anxiety disorder, and specific phobia,” American Journal of Psychiatry, vol. 164, no. 10, pp. 1476–1488, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Zhang, M. Brady, and S. Smith, “Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm,” IEEE Transactions on Medical Imaging, vol. 20, no. 1, pp. 45–57, 2001. View at Publisher · View at Google Scholar · View at Scopus