Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Cryptolepis buchanani Extract: In Vitro and In Vivo Studies
Table 3
Effects of CBE and indomethacin on carrageenan-induced hind paw edema in rats (n = 6).
Treatment
Edema volume (mL)
1st h
% EI
3rd h
% EI
5th h
% EI
80% Tween
0.36 ± 0.05
—
0.83 ± 0.05
—
0.74 ± 0.03
—
CBE 100 mg/kg
0.18 ± 0.02
51.61
0.55 ± 0.03*
33.78
0.57 ± 0.06
22.58
CBE 250 mg/kg
0.14 ± 0.02**
60.64
0.45 ± 0.03*
45.60
0.49 ± 0.06*
34.28
CBE 500 mg/kg
0.12 ± 0.03**
66.00
0.41 ± 0.07*
50.37
0.40 ± 0.05*
46.06
Indomethacin 10 mg/kg
0.06 ± 0.03**
82.39
0.25 ± 0.02**
70.32
0.31 ± 0.04**
58.36
Results are mean of edema volume ± S.E.M. % EI is percentage of edema volume inhibition of test compound. *P 0.05 and **P 0.01 compared with control group.
