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BioMed Research International
Volume 2014, Article ID 980429, 7 pages
http://dx.doi.org/10.1155/2014/980429
Research Article

Association between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome

1Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
2Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, Gynaecology and Obstetrics Unit A, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy

Received 4 February 2014; Revised 12 April 2014; Accepted 14 April 2014; Published 4 May 2014

Academic Editor: Irma Virant-Klun

Copyright © 2014 G. Garruti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group, “Consensus on women's health aspects of polycystic ovary syndrome (PCOS),” Human Reproduction, vol. 27, no. 1, pp. 14–24, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. R. S. Legro, D. Driscoll, J. F. Strauss III, J. Fox, and A. Dunaif, “Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 25, pp. 14956–14960, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. K. G. Ewens, M. R. Jones, W. Ankener et al., “FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome,” PLoS ONE, vol. 6, no. 1, Article ID e16390, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Dunaif, X. Wu, A. Lee, and E. Diamanti-Kandarakis, “Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS),” American Journal of Physiology: Endocrinology and Metabolism, vol. 281, no. 2, pp. E392–E399, 2001. View at Google Scholar · View at Scopus
  5. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman, “Positional cloning of the mouse obese gene and its human homologue,” Nature, vol. 372, no. 6505, pp. 425–432, 1994. View at Google Scholar
  6. G. Frϋhbeck, “Intracellular signalling pathways activated by leptin,” Biochemical Journal, vol. 393, part 1, pp. 7–20, 2006. View at Publisher · View at Google Scholar
  7. C. T. Montague, I. S. Farooqi, J. P. Whitehead et al., “Congenital leptin deficiency is associated with severe early-onset obesity in humans,” Nature, vol. 387, no. 6636, pp. 903–908, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Strobel, T. Issad, L. Camoin, M. Ozata, and A. D. Strosberg, “A leptin missense mutation associated with hypogonadism and morbid obesity,” Nature Genetics, vol. 18, no. 3, pp. 213–215, 1998. View at Google Scholar · View at Scopus
  9. C. S. Mantzoros, A. Dunaif, and J. S. Flier, “Leptin concentrations in the polycystic ovary syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 6, pp. 1687–1691, 1997. View at Google Scholar · View at Scopus
  10. S. B. Lecke, F. Mattei, D. M. Morsch, and P. M. Spritzer, “Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome,” Fertility and Sterility, vol. 95, no. 6, pp. 2044–2049, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Pasquali and A. Gambineri, “Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age,” Annals of the New York Academy of Sciences, vol. 1092, pp. 158–174, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Abir, A. Ao, S. Jin et al., “Leptin and its receptors in human fetal and adult ovaries,” Fertility and Sterility, vol. 84, no. 6, pp. 1779–1782, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. R. Ram, P. G. Sundararaman, and R. Malathi, “Body fat distribution and leptin correlation in women with polycystic ovary syndrome: endocrine and biochemical evaluation in south Indian population,” Reproductive Medicine and Biology, vol. 4, no. 1, pp. 71–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. M.-G. Li, G.-L. Ding, X.-J. Chen et al., “Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 12, pp. 4771–4776, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. G. De Placido, C. Alviggi, R. Clarizia et al., “Intra-follicular leptin concentration as a predictive factor for in vitro oocyte fertilization in assisted reproductive techniques,” Journal of Endocrinological Investigation, vol. 29, no. 8, pp. 719–726, 2006. View at Google Scholar · View at Scopus
  16. S. Savastano, R. Valentino, C. Di Somma et al., “Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS,” Nutrition and Metabolism, vol. 8, article 84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. B. Lecke, F. Mattei, D. M. Morsch, and P. M. Spritzer, “Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome,” Fertility and Sterility, vol. 95, no. 6, pp. 2044–2049, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Reverchon, M. Cornuau, L. Cloix et al., “Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis,” Molecular Human Reproduction, vol. 19, no. 5, pp. 313–326, 2013. View at Google Scholar
  19. K.-H. Choi, B.-S. Joo, S.-T. Sun et al., “Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice,” Fertility and Sterility, vol. 97, no. 5, pp. 1234–1241, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Garruti, R. Depalo, M. G. Vita et al., “Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment,” Reproductive BioMedicine Online, vol. 19, no. 4, pp. 552–563, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Depalo, F. Lorusso, M. Palmisano et al., “Follicular growth and oocyte maturation in GnRH agonist and antagonist protocols for invitro fertilisation and embryo transfer,” Gynecological Endocrinology, vol. 25, no. 5, pp. 328–334, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, “Report of the expert committee on the diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 20, no. 7, pp. 1183–1197, 1997. View at Google Scholar · View at Scopus
  23. D. Falagario, A. M. Brucculeri, R. Depalo, P. Trerotoli, E. Cittadini, and G. Ruvolo, “Sperm head vacuolization affects clinical outcome in ICSI cycle. A proposal of a cut-off value,” vol. 29, no. 11, pp. 1281–1287, 2012. View at Publisher · View at Google Scholar
  24. L. L. Veeck, Atlas of the Human Oocyte and Early Conceptus, Williams & Wilkins, Baltimore, Md, USA, 1986.
  25. D. R. Matthews, J. P. Hosker, and A. S. Rudenski, “Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Google Scholar · View at Scopus
  26. M. Matsuda and R. A. DeFronzo, “Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp,” Diabetes Care, vol. 22, no. 9, pp. 1462–1470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Armitage and G. Berry, Statistical Methods in Medical Research, Blackwell Science, Oxford, UK, 3rd edition, 1994.
  28. B. Dawson and R. G. Trapp, Basic & Clinical Biostatistics, Mc Graw-Hill, New York, NY, USA, 3rd edition, 2001.
  29. R. Azziz, K. S. Woods, R. Reyna, T. J. Key, E. S. Knochenhauer, and B. O. Yildiz, “The prevalence and features of the polycystic ovary syndrome in an unselected population,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2745–2749, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. R. A. Wild, E. Carmina, E. Diamanti-Kandarakis et al., “Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the androgen excess and polycystic ovary syndrome (AE-PCOS) society,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 5, pp. 2038–2049, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. C. J. Alexander, E. P. Tangchitnob, and N. E. Lepor, “Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women,” Reviews in Obstetrics & Gynecology, vol. 2, no. 4, pp. 232–239, 2009. View at Google Scholar · View at Scopus
  32. P. Zimmet, G. Alberti, and J. A. Shaw, “A new IDF worldwide definition of the metabolic syndrome: the rationale and the results,” Diabetes Voice, vol. 50, no. 3, pp. 31–33, 2005. View at Google Scholar
  33. Q. Lin, S. L. Poon, J. Chen, L. Cheng, B. HoYuen, and P. C. K. Leung, “Leptin interferes with 3′,5′-Cyclic Adenosine Monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells,” Reproductive Biology and Endocrinology, vol. 7, article 115, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Cervero, F. Dominguez, J. A. Horcajadas, A. Quinonero, A. Pellicer, and C. Simon, “The role of the leptin in reproduction,” Current Opinion in Obstetrics and Gynecology, vol. 18, no. 3, pp. 297–303, 2006. View at Publisher · View at Google Scholar
  35. S. Sam and A. Dunaif, “Polycystic ovary syndrome: syndrome XX?” Trends in Endocrinology and Metabolism, vol. 14, no. 8, pp. 365–370, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Corbould and A. Dunaif, “The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome,” Metabolism: Clinical and Experimental, vol. 56, no. 5, pp. 716–722, 2007. View at Publisher · View at Google Scholar · View at Scopus