Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury
Figure 2
Postinjury treatment of VPA improves skilled forelimb reaching task. All groups had a baseline performance without a significant difference. After TBI, the vehicle- and VPA-treated groups showed marked deficits in successfully obtaining pellets with the TBI-impaired limb, with no significant difference between groups until 7 days after injury. Animals that received VPA treatment, 30 mg/kg/day for 7 days began to exhibit improvements in the pellet reaching success rate at 7 days after TBI and showed a significant difference starting from 14 to 28 days after treatment, compared to TBI with vehicle-only animals (14 days, ; 21 days, ; 28 days, ). Data are presented as the mean ± SEM, significant difference by 1-way ANOVA with Tukey post hoc analysis.
