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BioMed Research International
Volume 2014, Article ID 980767, 11 pages
http://dx.doi.org/10.1155/2014/980767
Clinical Study

Clinical Study of Nasopharyngeal Carcinoma Treated by Helical Tomotherapy in China: 5-Year Outcomes

1Department of Radiation Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
2Department of Radiation Oncology, Hainan Branch of Chinese PLA General Hospital, Haitang Bay, Sanya 572000, China
3Department of Otorhinolaryngology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
4Department of Medical Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
5Department of Radiation Oncology, Monmouth Medical Center, 300 2nd Avenue, Long Branch, NJ 07740, USA

Received 21 February 2014; Accepted 25 May 2014; Published 9 July 2014

Academic Editor: Tsair-Fwu Lee

Copyright © 2014 Lei Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. W. Lo, K. F. To, and D. P. Huang, “Focus on nasopharyngeal carcinoma,” Cancer Cell, vol. 5, no. 5, pp. 423–428, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Lee, P. Xia, J. M. Quivey et al., “Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an uptade of the UCSF experience,” International Journal of Radiation Oncology Biology Physics, vol. 53, no. 1, pp. 12–22, 2002. View at Google Scholar · View at Scopus
  3. M. K. M. Kam, P. M. L. Teo, R. M. C. Chau et al., “Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience,” International Journal of Radiation Oncology Biology Physics, vol. 60, no. 5, pp. 1440–1450, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Lee, G. M. Back, B. Y. Yi et al., “Preliminary results of a phase I/II study of simultaneous modulated accelerated radiotherapy for nondisseminated nasopharyngeal carcinoma,” International Journal of Radiation Oncology Biology Physics, vol. 65, no. 1, pp. 152–160, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Lee, J. Harris, A. S. Garden et al., “Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225,” Journal of Clinical Oncology, vol. 27, no. 22, pp. 3684–3690, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. I. W. Tham, S. W. Hee, R. M. Yeo et al., “Treatment of nasopharyngeal carcinoma using intensity-modulated radiaotherapy—the national cancer centre Singapore experience,” International Journal of Radiation Oncology * Biology * Physics, vol. 75, no. 5, pp. 1481–1486, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Lin, J. J. Lu, L. Han, Q. Chen, and J. Pan, “Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: Experience of 370 consecutive cases,” BMC Cancer, vol. 10, article 39, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. W. T. Ng, M. C. H. Lee, W. M. Hung et al., “Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma,” International Journal of Radiation Oncology Biology Physics, vol. 79, no. 2, pp. 420–428, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Su, F. Han, C. Zhao et al., “Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone,” International Journal of Radiation Oncology Biology Physics, vol. 82, no. 1, pp. 327–333, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Z. Lai, W. F. Li, L. Chen et al., “How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?” International Journal of Radiation Oncology, Biology, Physics, vol. 80, no. 3, pp. 661–668, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Peng, T. Wang, K. Yang et al., “A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma,” Radiotherapy and Oncology, vol. 104, no. 3, pp. 286–293, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Bauman, S. Yartsev, G. Rodrigues et al., “A prospective evaluation of helical tomotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 68, no. 2, pp. 632–641, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Kodaira, N. Tomita, H. Tachibana et al., “Aichi Cancer Center Initial Experience of Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer Using Helical Tomotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 73, no. 4, pp. 1129–1134, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. M. Chen, R. L. S. Jennelle, R. Sreeraman et al., “Initial clinical experience with helical tomotherapy for head and neck cancer,” Head & Neck, vol. 31, no. 12, pp. 1571–1578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Ren, L. Du, L. Ma et al., “Clinical observation of 73 nasopharyngeal carcinoma patients treated by helical tomotherapy: the China experience,” Technology in Cancer Research and Treatment, vol. 10, no. 3, pp. 259–266, 2011. View at Google Scholar · View at Scopus
  16. RTOG H-0022, “Phase I/II study of conformal and intensity modulated irradiation for oropharyngeal cancer,” 2002, http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx?study=0022.
  17. J. D. Cox, J. Stetz, and T. F. Pajak, “Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC),” International Journal of Radiation Oncology Biology Physics, vol. 31, no. 5, pp. 1341–1346, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. T. R. Mackie, T. Holmes, S. Swerdloff et al., “Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy,” Medical Physics, vol. 20, no. 6, pp. 1709–1719, 1993. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Cui, X. K. Dai, L. Ma et al., “A dosimetric comparison of helical tomotherapy treatment plans and linear accelerator-based IMRT for nasopharyngeal carcinomas,” Chinese Journal of Radiation Oncology, vol. 17, pp. 169–173, 2008 (Chinese). View at Google Scholar
  20. T. F. Lee, F. M. Fang, P. J. Chao, T. J. Su, L. K. Wang, and S. W. Leung, “Dosimetric comparisons of helical tomotherapy and step-and-shoot intensity-modulated radiotherapy in nasopharyngeal carcinoma,” Radiotherapy and Oncology, vol. 89, no. 1, pp. 89–96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Fiorino, I. Dell'Oca, A. Pierelli et al., “Simultaneous integrated boost (SIB) for nasopharynx cancer with helical tomotherapy: a planning study,” Strahlentherapie und Onkologie, vol. 183, no. 9, pp. 497–505, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. S. H. Lu, J. C. Cheng, S. H. Kuo et al., “Volumetric modulated arc therapy for nasopharyngeal carcinoma: a dosimetric comparison with TomoTherapy and step-and-shoot IMRT,” Radiotherapy and Oncology, vol. 104, no. 3, pp. 324–330, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Al-Sarraf, M. LeBlanc, P. G. S. Giri et al., “Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099,” Journal of Clinical Oncology, vol. 16, no. 4, pp. 1310–1317, 1998. View at Google Scholar · View at Scopus
  24. M. Huncharek and B. Kupelnick, “Combined chemoradiation versus radiation therapy alone in locally advanced nasopharyngeal carcinoma: Results of a meta-analysis of 1,528 patients from six randomized trials,” American Journal of Clinical Oncology, vol. 25, no. 3, pp. 219–223, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. Langendijk, C. R. Leemans, J. Buter, J. Berkhof, and B. J. Slotman, “The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature,” Journal of Clinical Oncology, vol. 22, no. 22, pp. 4604–4612, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Baujat, H. Audry, J. Bourhis et al., “Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients,” International Journal of Radiation Oncology Biology Physics, vol. 64, no. 1, pp. 47–56, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Zhang, C. Zhao, B. Ghimire et al., “The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase iii randomized trials,” BMC Cancer, vol. 10, article 558, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. A. W. M. Lee, S. Y. Tung, D. T. T. Chua et al., “Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma,” Journal of the National Cancer Institute, vol. 102, no. 15, pp. 1188–1198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Wang, M. Shi, Y. Hsia et al., “Failure patterns and survival in patients with nasopharyngeal carcinoma treated with intensity modulated radiation in Northwest China: a pilot study,” Radiation Oncology, vol. 7, no. 1, pp. 2–13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. J. A. Bonner, P. M. Harari, J. Giralt et al., “Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival,” The Lancet Oncology, vol. 11, no. 1, pp. 21–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. A. T. C. Chan, M. Hsu, B. C. Goh et al., “Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma,” Journal of Clinical Oncology, vol. 23, no. 15, pp. 3568–3576, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. X. D. Huang, J. L. Yi, L. Gao et al., “Multi-center phase II clinical trial of humanized anti-epidermal factor receptor monoclonal antibody h-R3 combined with radiotherapy for locoregionally advanced nasopharyngeal carcinoma,” Zhonghua Zhong Liu Za Zhi, vol. 29, no. 3, pp. 197–201, 2007. View at Google Scholar · View at Scopus
  33. T. Crombet, M. Osorio, T. Cruz et al., “Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients,” Journal of Clinical Oncology, vol. 22, no. 9, pp. 1646–1654, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Zhou, H. Ying, C. Hu et al., “Preliminary results of re-irradiation for locally recurrent nasopharyngeal carcinoma with intensity modulated radiotherapy,” International Journal of Radiation Oncology, Biology, Physics, vol. 78, no. 3, supplement, p. S468, 2010. View at Publisher · View at Google Scholar
  35. Y. Goto, J. Ito, N. Tomita, H. Tachibana, K. Furutani, and T. Kodaria, “Re-irradiation combined with concurrent chemotherapy for patients with locally recurrent nasopharyngeal carcinoma: clinical advantage of intensity modulated radiotherapy using helical tomotherapy,” International Journal of Radiation Oncology, Biology, Physics, vol. 78, article S460, 2010. View at Google Scholar
  36. K. P. Chang, S. P. Hao, N. M. Tsang, and S. H. Ueng, “Salvage surgery for locally recurrent nasopharyngeal carcinoma—a 10-year experience,” Otolaryngology—Head and Neck Surgery, vol. 131, no. 4, pp. 497–502, 2004. View at Publisher · View at Google Scholar · View at Scopus