Bone Marrow Plasma Cell Assessment before Peripheral Blood Stem Cell Mobilization in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation

Table 3

Multivariate analysis of independent factors affecting survival outcomes.

Variable	E/N *	RR (95% CI)	P value
Progression-free survival
Cytogenetics
Standard	39/88	1
High risk	14/18	2.05 (1.10–3.84)	0.024
Response before PBSC mobilization†
<5% + CR	13/35	1
<5% + non-CR	20/38	2.02 (1.00–4.11)	0.050
≥5% + CR	2/4	1.52 (0.34–6.78)	0.583
≥5% + non-CR	18/29	3.60 (1.69–7.63)	0.001
Overall survival
Sex
Male	10/59	1
Female	2/47	0.29 (0.06–1.33)	0.109
Cytogenetics
Standard	6/88	1
High risk	6/18	3.92 (1.20–12.81)	0.024
Ca at diagnosis
<10 mg/dL	7/87	1
≥10 mg/dL	5/19	2.14 (0.65–7.06)	0.214

CR: complete response; non-CR: noncomplete response; RR: relative risk.
* E/N: number of events/number of evaluable patients.
^†BMPCs + serologic CR.