Review Article
Fluid Resuscitation in Sepsis: Reexamining the Paradigm
Table 2
Summary of studies evaluating colloids.
| Author | Year | Study design | Sample size | Study fluid | Primary endpoint | Comments |
|
Schierhout and Roberts [55] | 1998 | Meta-analysis | 1315 | All colloids | Mortality | Increased mortality |
| Laxenaire et al. [56] | 1994 | Multicentre prospective | 19593 | All colloids | Adverse effects | Gelatins and dextrans-independent risk for anaphylactoid reactions |
| Myburgh et al. [61] | 2012 | RCTa | 7000 | HESb versus 0.9% saline | 90-day mortality | HESb associated with increased incidence of RRT |
| Perner et al. [62] | 2012 | RCTa | 804 | HESb versus Ringer’s acetate | Death/dialysis dependence at 90 days | Death and dialysis dependence more in HES |
| Zarychanski et al. [63] | 2013 | Meta-analysis | 10,290 | HESb | Mortality and AKIc | Significant increase in risk of mortality and AKIc |
| Guidet et al. [64] | 2012 | RCTa | 196 | HESb versus 0.9% saline | Hemodynamic efficacy and safety | HESb better hemodynamic efficacy and no difference in AKIc |
| Finfer et al. [67] | 2004 | RCTa | 6997 | Albumin versus 0.9% saline | 28-day mortality | No difference |
| Myburgh et al. [72] | 2007 | Post hoc analysis of SAFE trial | 460 | Albumin versus 0.9% saline | Safety in TBId | Albumin unsafe for TBId |
| Delaney et al. [68] | 2011 | Meta-analysis | 1977 | Albumin | Safety for resuscitation | Albumin associated with lower mortality |
| Annane et al. [69] | 2013 | RCTa | 2857 | Colloids versus crystalloids |
28-day mortality | No difference |
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Table summarizing studies evaluating colloids. aRandomized Controlled Trial, bHydroxyethyl starch, cAcute Kidney Injury, dTraumatic Brain Injury.
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