Arrabidaea chica Hexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition on Leishmania spp.

Table 1

Antileishmanial activity and cytotoxic effect of the A. chica hexanic extract fractions.

Hexanic extract fraction	L. amazonensis		L. infantum		Macrophages	SI
	MIC (𝜇g/mL)	IC50 (𝜇g/mL)	MIC (𝜇g/mL)	IC50 (𝜇g/mL)	MCC (𝜇g/mL)
B1	na	nd	na	nd	nd	nd
B2	37.2	31.8	18.6	14.7	297.6	8.0^a/16^b
B3	186.7	152.2	186.7	139.6	nd	nd
B4	368	198.5	368	179.7	nd	nd
B5	na	nd	na	nd	nd	nd
Amphotericin B	1.01	0.07	0.625	0.01	14.6	14.4^a/23.4^b

MIC: minimum inhibitory concentration; IC₅₀: 50% inhibitory concentration; MCC: minimum cytotoxic concentration.
na: not active at the highest concentration tested (500 𝜇g/mL); nd: not determined.
SI: selective index; ^aselective index for L. amazonensis; ^bselective index for L. infantum.