Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4⁺ T Cells

Figure 1

HQT ameliorates TNBS-induced colitis in a dose-dependent manner. Various doses of Huangqin-Tang decoction (HQT) (30–120 mg/kg) were administered following the 2,4,6-trinitrobenzenesulfonic acid (TNBS) enema and on the next 2 days. (a) Body weight changes (percentage of original body weight), (b) bleeding score, and (c) diarrhoea score were scored daily. (d) Rats were sacrificed on day 7 to measure colon length. (e) Myeloperoxidase (MPO) activity was assessed in colon homogenates as described in Section 2. (f) The production of tumor necrosis factor-α (TNF-α) in the colon was determined by enzyme-linked immunosorbent assay (ELISA). Results represent the mean ± SD from eight mice per group. , versus the control group. ^Δ, ^ΔΔ versus TNBS-treated rats.

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