Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus
α-AA effect on the NMDA-induced astroglial reaction in the hippocampus. GFAP-immunostaining 1 (a) and 3 days (b) in sham animals, 1 (c) and 3 days (d) after α-AA, 1 (e) and 3 days (f) after NMDA lesion, and 1 (g) and 3 days (h) after α-AA + NMDA injection (arrowheads show the injection site). Please note in (c) and (g) the lack of GFAP-immunopositive cells in the surroundings of the injection site. Graphs show the quantification of the area of astrogliosis in the whole hippocampus. (i) GFAP-immunostained and S100B-immunostained (j) sections of sham (PBS), α-AA, NMDA, and α-AA + NMDA rats at postlesion days 1, 3, 15, and 38. (k) Graph shows the estimation of the ratio S100B/GFAP, calculated as the quotient between the area of increased S100B and the area of increased GFAP in these rats. Photomicrographs illustrate GFAP-immunoreactive cells of NMDA (l) and α-AA + NMDA (m) rats and S100B-immunoreactive cells of MNDA (n) and α-AA + NMDA (o) rats in the hippocampal parenchyma 3 days after the lesion. different from PBS; # different from NMDA; different from day 15 (LSD post hoc test) ( rats/group). Bar: 1 mm in (a)–(h) and 10 μm in (l)–(o).
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