Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Figure 3

Renal tubules of E1-DN mice show morphological changes and increased proliferation. ((a), (b)) Hematoxylin and eosin staining shows flattened tubular epithelial cells in the albuminuric E1-DN homozygous mice (b) when compared to normal tall cuboidal epithelium in the wild-type mice (a). ((c), (d)) Immunostaining for Ki-67 reveals only occasional proliferating cells in the wild-type mice (c), whereas in the albuminuric E1-DN homozygous mice groups of proliferating cells are observed (d). Scale bar: 50 μm ((a), (b)); 25 μm ((c), (d)).

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