Effect of Sodium Benzoate Preservative on Micronucleus Induction, Chromosome Break, and Ala40Thr Superoxide Dismutase Gene Mutation in Lymphocytes

Table 1

Effect of four sodium benzoate concentrations at 24 and 48 hrs on micronucleus formation in lymphocytes.

Treated substance	Treatment		MN ± SE (%)
	Period (hrs)	Conc. (mg/mL)
Control	24	0	42.88 ± 2.88
SB	24	0.5	51.52 ± 1.62
	24	1.0	66.67 ± 2.10^*
	24	1.5	69.23 ± 1.36^*
	24	2.0	86.67 ± 1.77^*
Control	48	0	50.00 ± 2.88
SB	48	0.5	63.64 ± 1.01^*
	48	1.0	69.23 ± 1.05^*
	48	1.5	78.57 ± 1.17^*
	48	2.0	93.64 ± 1.42^*

Significantly different from the control ( < 0.05).
SB: sodium benzoate.
MN: micronucleated cell.