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BioMed Research International
Volume 2015 (2015), Article ID 105629, 7 pages
http://dx.doi.org/10.1155/2015/105629
Research Article

Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

1Department of Imaging Methods, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic
2Department of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic
3Department of Internal Medicine, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic
4Department of Surgery, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic
5Siemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, Germany

Received 15 April 2015; Revised 16 June 2015; Accepted 22 June 2015

Academic Editor: Sara Seitun

Copyright © 2015 Jan Baxa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, ; per-vessel: specificity 95 versus 75%, ) and high overruling rate of rsCTP was proved in intermediate stenosis (40–70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.