A Novel Mouse Model of Peritoneal Dialysis: Combination of Uraemia and Long-Term Exposure to PD Fluid

Figure 1

Experimental design. 5/6 nephrectomy was executed at day 1. After a resting period of 10 days a customer made catheter was implanted under the skin at the back side with the tip positioned within the peritoneal membrane. Daily PD fluid instillation was performed from day 16 to day 70 when the mice were sacrificed; PET test and tissue sampling were carried out. Blood withdrawal was performed at days 0, 15, and 70 in order to verify uraemia establishment.