Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway

Figure 1

Sevoflurane-induced cognitive impairment in 6-day-old mice. (a) Mice that were exposed to 3% sevoflurane for 2 h daily from postnatal day 6 (P6) to P8 exhibited increased escape latency at P30–P34 in the Morris water maze (MWM), compared with control mice (control: ; sevoflurane: ). Results from two-way analysis of variance (ANOVA) with repeated measurement analysis showed that there was a statistically significant interaction between time and group, based on the escape latency of the MWM. The post hoc Bonferroni test showed that the mice that received sevoflurane anesthesia had longer escape latency than the mice following the control condition on P33 and P34. (b) Platform crossing times were reduced in mice (P34) that were exposed to 3% sevoflurane for 2 h daily from P6 to P8 (control: ; sevoflurane: ).

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