Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway

Figure 4

Sevoflurane-induced neuronal apoptosis and neurogenesis inhibition through the PPARγ signaling pathway in 6-day-old mice. (a-b) Exposure of P6 mice to sevoflurane for 2 h daily for 3 days induced neurogenesis inhibition. (c-d) RSG attenuated sevoflurane-induced neurogenesis inhibition. (e) There was a statistically significant difference in the number of 5-bromodeoxyuridine- (BrdU-) positive cells between sevoflurane-treated mice and sevoflurane + RSG-treated mice (two-way ANOVA; sevoflurane: ; sevoflurane + RSG: ). IOD: integrated optical density.