Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway

Figure 6

EE attenuated sevoflurane-induced neuronal apoptosis and neurogenesis inhibition through the PPARγ signaling pathway. (a-b) Multiple sevoflurane exposures from P6 to P8 induced neurogenesis inhibition in young mice (P30). (c-d) EE attenuated sevoflurane-induced neurogenesis inhibition. (e) The number of BrdU-positive cells was significantly different between mice that were exposed to sevoflurane and mice that were exposed to both sevoflurane and EE (two-way ANOVA; sevoflurane: ; sevoflurane + EE: ).