Preparation and Characterization of Solid Dispersions of Artemether by Freeze-Dried Method

Table 1

Kinetic analysis of dissolution data.

Formulations	Zero order model		First order model		Higuchi model		Korsmeyer-Peppas model
	Pure ARTM	0.013	0.7857	0.000	0.7913	0.171	0.9569	0.549
Physical mixture of group-1	0.036	0.5417	0.000	0.5622	0.478	0.8383	0.459
Freeze-dried mixture of group-1	0.044	0.5961	0.000	0.6199	0.589	0.8535	0.483
Physical mixture of group-2	0.181	0.5622	0.002	0.6719	2.403	0.8322	0.473
Freeze-dried mixture of group-2	0.194	0.5651	0.003	0.6839	2.573	0.8336	0.475
Physical mixture of group-3	0.115	0.5002	0.001	0.5739	1.546	0.8346	0.437
Freeze-dried mixture of group-3	0.227	0.5121	0.003	0.6677	3.035	0.8215	0.450