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BioMed Research International
Volume 2015, Article ID 109656, 9 pages
http://dx.doi.org/10.1155/2015/109656
Research Article

Molecular Identification and Susceptibility of Clinically Relevant Scedosporium spp. in China

Hong Wang,1,2 Zhe Wan,1,2 Ruoyu Li,1,2 Qiaoyun Lu,3 and Jin Yu1,2

1Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing 100034, China
2Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China
3Department of Dermatology, Central Hospital of Xiangyang, Hubei College of Arts and Science, Hubei 441021, China

Received 25 July 2015; Accepted 16 September 2015

Academic Editor: Orazio Romeo

Copyright © 2015 Hong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As various new sibling species within the Scedosporium spp. have been described recently, this study was conducted to investigate distribution and antifungal susceptibility profiles of the different species of Scedosporium spp. in China. Twenty-one clinical strains of Scedosporium from China and two strains from Japan were reidentified by MLSA. The analysis included BT2, CAL, RPB, SOD, and ACT and the combination of the five loci. Pseudallescheria boydii complex (17 strains) and S. apiospermum (6 strains) were identified. P. boydii complex included four closely related subgroups: P. boydii (9 strains), P. ellipsoidea (6 strains), P. fusoidea (1 strain), and P. angusta (1 strain). There were no significant differences in MICs for neither VOR, POS, nor AMB over all the five species in study. For itraconazole, intraspecific diversity was evident.