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BioMed Research International
Volume 2015, Article ID 120903, 5 pages
http://dx.doi.org/10.1155/2015/120903
Clinical Study

Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy

1Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany
2Department of Oral and Maxillofacial Surgery, General Hospital Balingen, Tübinger Straße 30, 72336 Balingen, Germany
3Department of Pathology, General Hospital Nürtingen, Auf dem Säer 1, 72622 Nürtingen, Germany

Received 8 May 2015; Accepted 2 August 2015

Academic Editor: Kosmas Paraskevas

Copyright © 2015 Wolfgang Eichhorn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. http://www.awmf.org/leitlinien/detail/ll/053-041.html.
  2. A. Gröbe, M. Fraederich, R. Smeets et al., “Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy,” BioMed Research International, vol. 2015, Article ID 823651, 4 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. J. N. George and S. J. Shattil, “The clinical importance of acquired abnormalities of platelet function,” The New England Journal of Medicine, vol. 324, no. 1, pp. 27–39, 1991. View at Publisher · View at Google Scholar · View at Scopus
  4. P. J. Sharis, C. P. Cannon, and J. Loscalzo, “The antiplatelet effects of ticlopidine and clopidogrel,” Annals of Internal Medicine, vol. 129, no. 5, pp. 394–405, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. C. P. Cannon, “Oral platelet glycoprotein IIb/IIIa receptor inhibitors—part I,” Clinical Cardiology, vol. 26, no. 8, pp. 358–364, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. CAPRIE Steering Committee, “A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee,” The Lancet, vol. 348, no. 9038, pp. 1329–1339, 1996. View at Google Scholar
  7. H. L. Lutsep, “MATCH results: implications for the internist,” American Journal of Medicine, vol. 119, no. 6, pp. 526.e1–526.e7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Yusuf, S. Mehta, S. Anand et al., “The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease,” European Heart Journal, vol. 21, no. 24, pp. 2033–2041, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. D. G. Brown, E. C. Wilkerson, and W. E. Love, “A review of traditional and novel oral anticoagulant and antiplatelet therapy for dermatologists and dermatologic surgeons,” Journal of the American Academy of Dermatology, vol. 72, no. 3, pp. 524–534, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. A. M. Al-Harkan and G. A. Al-Ayoub, “Should antiplatelet and anticoagulant medications be discontinued before minor oral surgery procedures?” Journal of the Canadian Dental Association, vol. 78, article c24, 2012. View at Google Scholar · View at Scopus
  11. P.-G. Chassot, A. Delabays, and D. R. Spahn, “Perioperative use of anti-platelet drugs,” Best Practice and Research: Clinical Anaesthesiology, vol. 21, no. 2, pp. 241–256, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. N. G. Daniel, J. Goulet, M. Bergeron, R. Paquin, and P. E. Landry, “Antiplatelet drugs: is there a surgical risk?” Journal of the Canadian Dental Association, vol. 68, no. 11, pp. 683–687, 2002. View at Google Scholar
  13. J. S. Bordeaux, K. J. Martires, D. Goldberg, S. F. Pattee, P. Fu, and M. E. Maloney, “Prospective evaluation of dermatologic surgery complications including patients on multiple antiplatelet and anticoagulant medications,” Journal of the American Academy of Dermatology, vol. 65, no. 3, pp. 576–583, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. R. H. Cook-Norris, J. D. Michaels, A. L. Weaver et al., “Complications of cutaneous surgery in patients taking clopidogrel-containing anticoagulation,” Journal of the American Academy of Dermatology, vol. 65, no. 3, pp. 584–591, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Aldridge and L. L. Cunningham Jr., “Current thoughts on treatment of patients receiving anticoagulation therapy,” Journal of Oral and Maxillofacial Surgery, vol. 68, no. 11, pp. 2879–2887, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Eichhorn, J. Burkert, O. Vorwig et al., “Bleeding incidence after oral surgery with continued oral anticoagulation,” Clinical Oral Investigations, vol. 16, no. 5, pp. 1371–1376, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Rossini, D. Capodanno, C. Lettieri et al., “Prevalence, predictors, and long-term prognosis of premature discontinuation of oral antiplatelet therapy after drug eluting stent implantation,” The American Journal of Cardiology, vol. 107, no. 2, pp. 186–194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. J. D. Douketis, A. C. Spyropoulos, F. A. Spencer et al., “Perioperative management of antithrombotic therapy. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines,” Chest, vol. 141, no. 2, supplement, pp. e326–e350, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. B. A. Steinberg, E. D. Peterson, S. Kim et al., “Use and outcomes associated with bridging during anticoagulation interruptions in patients with atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF),” Circulation, vol. 131, no. 5, pp. 488–494, 2015. View at Google Scholar
  20. A. Rahman and J. Latona, “New oral anticoagulants and perioperative management of anticoagulant/antiplatelet agents,” Australian Family Physician, vol. 43, no. 12, pp. 861–866, 2014. View at Google Scholar · View at Scopus