Proteomic Study to Survey the CIGB-552 Antitumor Effect
Table 2
Functional subnetworks perturbed by CIGB-552.
Perturbed functional subnetworks
GO id.
Nodes
Targets
Score
Insulin receptor signaling pathway
GO:0008286
57
15
0.175
Positive regulation of biosynthetic process
GO:0009891
73
19
0.173
Positive regulation of NF-κB transcription factor activity
GO:0051092
40
14
0.165
Protein autoprocessing
GO:0016540
67
14
0.165
Extracellular structure organization
GO:0043062
66
13
0.143
Mitochondrion organization
GO:0007005
68
17
0.136
Antiapoptosis
GO:0006916
178
26
0.112
Interleukin-6 production
GO:0032635
21
8
0.105
Response to hypoxia
GO:0001666
68
14
0.103
Negative regulation of cell cycle
GO:0045786
37
8
0.076
GO id.: Gene Ontology identifier. Number of proteins related to the functional subnetwork and identified as potential CIGB-552 targets. : score calculated by drugDisruptNet, predicting the impact of CIGB-552 over the functional subnetwork.
