Serine-threonine kinase receptor-associated protein
STRAP
80.3
2.9
3.7
4.5
P26640
Valyl-tRNA synthetase
VARS
54.77
1.7
3
3.5
Q86VP1
Tax1-binding protein 1
TAX1BP1
31.29
2.3
11.7
1.2
Q9HD45
Transmembrane 9 superfamily member 3
TM9SF3
71.54
1.5
3.1
−1.8
P55327
Tumor protein D52
TPD52
64.69
5.9
1.8
1.8
P38606
V-type proton ATPase catalytic subunit A
ATP6V1A
66.31
−1.2
4.4
2.8
P45880
Voltage-dependent anion-selective channel protein 2
VDAC2
59.14
2.1
4
2
UniProtKB/Swiss-Prot entry accession number (http://www.uniprot.org/). The UniProt accession numbers highlighted in bold indicate those proteins (8) that were also identified by chemical proteomics. Recommended gene name (official gene symbol) as provided by UniProtKB/Swiss-Prot. MASCOT protein score. Fold change of differentially regulated proteins after 40 min, 2 h, and 5 h of treatment with CIGB-552 [(−) downregulated]. For each incubation time with CIGB-552, is given the fold change threshold to consider a protein significantly up- or downregulated. The fold changes that have an absolute value higher than the threshold are highlighted in boldface.