Gene Knockout Identification Using an Extension of Bees Hill Flux Balance Analysis

Table 4

Comparison between different methods for production of Lactic acid by E. coli.

Method	Growth rate (1/hr)	BPCY	List of knockout genes
BHFBA	0.62501	5.2241	FBP, PGK, ACALD
BAFBA [9]	0.58586	3.5656	GAPD, L_LACD2, PTAr
SA + FBA [5]	N/A	0.39850	ACLD19, DRPA, GLYCDx, F6PA, TPI, LDH_D2, EDA, TKT2, LDH_D-
OptKnock [3]	0.28	N/A	ACKr, PTAr, ACALD

Note. The bold numbers represent the best result. N/A: not applicable. Common genes in either 2 methods. BPCY is in gram (gram-glucose·hour)⁻¹.