Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents
Table 1
Hemodynamics during experimental protocol.
Baseline
15 min ischemia
2 hr reperfusion
HR
MAP
RPP
HR
MAP
RPP
HR
MAP
RPP
Vehicle
7
375 ± 20
121 ± 5
51 ± 2
367 ± 20
106 ± 9
41 ± 2
366 ± 18
78 ± 8
36 ± 2
MOR
7
382 ± 23
121 ± 6
47 ± 3
378 ± 23
111 ± 7
42 ± 5
338 ± 35
65 ± 4
27 ± 2
RAD + MOR
7
343 ± 9
111 ± 5
45 ± 2
304 ± 13
74 ± 5
27 ± 2
311 ± 11
66 ± 4
28 ± 2
DSG + MOR
7
346 ± 9
127 ± 3
50 ± 3
347 ± 7
117 ± 6
45 ± 2
296 ± 9
82 ± 7
30 ± 2
SB21
7
401 ± 8
108 ± 7
46 ± 4
395 ± 11
106 ± 10
44 ± 5
360 ± 12
81 ± 4
32 ± 2
RAD + SB
7
376 ± 11
107 ± 7
45 ± 3
363 ± 12
69 ± 5
28 ± 2
371 ± 13
72 ± 4
33 ± 2
DSG + SB
5
384 ± 8
124 ± 4
56 ± 2
384 ± 6
107 ± 7
45 ± 3
380 ± 8
79 ± 3
37 ± 1
RAD
7
361 ± 12
125 ± 5
52 ± 2
355 ± 10
129 ± 5
50 ± 2
333 ± 10
77 ± 4
33 ± 2
DSG
6
392 ± 7
110 ± 4
50 ± 1
388 ± 5
94 ± 10
42 ± 3
375 ± 7
78 ± 6
36 ± 3
Heart rate (HR), mean blood pressure (MAP), and rate pressure product (RPP), assessed at baseline, during ischemia and at 2 hours of reperfusion. Data presented as mean ± SEM. versus control.
