Biochemical and Functional Comparisons of mdx and Sgcg−/− Muscular Dystrophy Mouse Models
The Sgcg−/− D2 mice consistently had a more severe respiratory phenotype by plethysmography then the mdx animals. (a) At 8 and 16 weeks the Sgcg−/− D2 mice breathed significantly slower than the Sgcg+/+ D2 mice. At 16 weeks the Sgcg−/− D2 mice also breathed significantly slower than the mdx mice. (b) Sgcg−/− D2 mice inhaled (Ti) slower than the mdx mice at 4 and 16 weeks. (c) Sgcg−/− D2 mice had a lower peak inspiratory flow (PIFb) than the mdx mice at all-time points and lower than the Sgcg+/+ D2 mice at 4 and 8 weeks. (d) Sgcg−/− D2 mice exhaled slower than the mdx mice at 12 and 16 weeks. (e) Sgcg−/− D2 mice had a lower peak expiratory flow (PEFb) than the mdx mice at all-time points and lower flow than the Sgcg+/+ D2 at 8 weeks. , significance versus Sgcg−/− D2 animals. Sgcg+/+ D2 at 12 weeks , all others –10.
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