Biochemical and Functional Comparisons of mdx and Sgcg^−/− Muscular Dystrophy Mouse Models

Figure 7

The mdx mice demonstrated a more severe cardiac functional pathology. (a) Sgcg^−/− D2 mice had a shorter isovolumetric relaxation time (IVRT) than the mdx mice at all-time points. (b) The Sgcg^−/− mice have a higher fractional shortening (FS%). (c) Sgcg^−/− have a greater ejection fraction (EF%) than the mdx mice at 4, 8, and 12 weeks. (d) Pulmonary artery acceleration time (PA AT) was lower in the Sgcg^−/− mice at 8 weeks compared to the mdx mice. , significance versus Sgcg^−/− D2 animals. Sgcg^+/+ D2 at 4 weeks , all others –23.

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