The Fine LINE: Methylation Drawing the Cancer Landscape

Figure 1

Biology of the LINE-1 element. The LINE-1 element is composed of four units (1). A decrease in silencing methylation marks at CpG dinucleotides (2) may induce an increase in LINE-1 transcription (3). The proteins ORF1p and ORF2p (4) encoded in LINE-1 contribute to its reinsertion in the genome (5).