Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

Table 4

Assessment of correlation between Ki-67 expression and pathological data.

	Ki-67 in CRC			Ki-67 in lymph node metastasis
		Positive (%)			Positive (%)
Tumor size
≤4.5 cm	279	190 (68.1)	0.519	65	39 (60.0)	0.211
>4.5 cm	179	127 (70.9)		40	19 (47.5)
Histological type
Adenocarcinoma	409	281 (68.7)	0.665	88	46 (52.3)	0.483
Mucinous adenocarcinoma	50	32 (64.0)		13	8 (61.5)
Invasive adenocarcinoma	24	18 (75.0)		6	4 (66.7)
Signet ring and mucinous	4	2 (50.0)		2	2 (100.0)
Differentiation
Well differentiated	209	135 (64.6)	0.049	38	19 (50.0)	0.670
Moderately differentiated	208	146 (70.2)		46	26 (56.5)
Poorly differentiated	47	40 (85.1)		23	14 (60.9)
Undifferentiated	4	3 (75.0)		1	1 (100.0)
Tumour penetration
pT1	34	23 (79.3)	0.013	2	2 (100.0)	0.553
pT2	57	39 (68.4)		4	2 (50.0)
pT3	370	252 (68.1)		96	53 (55.2)
pT4	26	19 (73.1)		7	3 (42.9)
Spread to lymph nodes
Absent	275	188 (68.4)	0.940	9	5 (55.6)	1.000^*
Present	198	136 (68.7)		89	50 (56.2)
Venous vessel invasion
Absent	264	179 (67.8)	0.511	29	13 (44.8)	0.110
Present	201	142 (70.4)		74	46 (62.2)
TNM
Stage I	75	54 (72.0)	0.425
Stage II	181	121 (66.9)
Stage III	152	108 (71.1)		78	43 (55.1)	0.978
Stage IV	70	45 (64.3)		31	17 (54.8)

Comparisons were examined for statistical significance using Fisher’s exact test (when ).