SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson’s Disease in Chinese and Australians

Table 2

SNCA but not MAPT gene associates with age of PD onset (Random-Effects Models).

Cohorts	SNPs	Genetic Inheritance Model	Number	value	value
Australians; (123 cases)	SNCA; D4S3481	Genotypes (00, 01, 02, 11, 12, 22)	14, 34, 6, 51, 15, 3	3.953	0.002
		Allele 0 carrier status (2, 1, 0)	14, 40, 69	5.606	0.005
		Dominant (2 + 1, 0)	54, 69	11.291	0.001
		Recessive (2, 1 + 0)	14, 109	1.996	0.160
		Allele 1 carrier status (2, 1, 0)	51, 49, 23	8.408	<0.001
		Dominant (2 + 1, 0)	100, 23	8.742	0.004
		Recessive (2, 1 + 0)	51, 72	13.840	<0.001
		Allele 2 carrier status (2, 1, 0)	3, 21, 99	1.966	0.145
		^*Dominant (2 + 1, 0)	24, 99	1.853	0.176
	MAPT; ^*rs17650901	Dominant (GG + AG versus AA)	86 versus 37	3.272	0.073
Chinese; (289 cases)	SNCA
	rs11931074	Dominant (GG + GT versus TT)	172 versus 117	0.638	0.425
		Recessive (GG versus GT + TT)	46 versus 243	0.358	0.550
		Additive (GG versus GT versus TT)	46 versus 126 versus 117	0.374	0.689
	rs894278	Dominant (GG + GT versus TT)	182 versus 107	0.665	0.415
		Recessive (GG versus GT + TT)	47 versus 242	5.20	0.023
		Additive (GG versus GT versus TT)	47 versus 135 versus 107	2.592	0.077
	MAPT
	rs2425577	Dominant (GG + GA versus AA)	190 versus 99	0.583	0.446
		Recessive (GG versus GA + AA)	55 versus 234	0.026	0.871
		Additive (GG versus GA versus AA)	55 versus 135 versus 99	0.297	0.744
	^*rs3744456	Dominant (CC + CG versus GG)	77 versus 212	1.574	0.211

Only dominant inheriting pattern is adopted due to rare minor allele frequency of the homozygote.